Warwickshire Fire and Rescue received a call to Junction 15 to an incident which took place between junctions 15 and 16 of the M40.
Two fire engines from Leamington were mobilised.
The incident involved a collision between a car and a 4×4 towing a horsebox.
Nobody was trapped in the vehicles.
Crews waited in attendance for the arrival of a vet to sedate and transfer a horse into another trailer.